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1.
To completely screw something up;
To destroy or masacre;
To make something that would be otherwise good, absolutely unbearable;
To completely 'fuck up' something;

Can be synonymus with: annihilate, decimate, murder, slaughhter, butcher, ruin, wreck, oblitherate, etc.
"Dude, they totally m squared that play."

"Man, did you see that chick's face - it looked so m squared."
av disgruntled punter 10. august 2009
 
2.
Short for Mac Miller
"Bro, you hear that M Squared last night? That shit was ill"
av MacFlow 6. januar 2013
 
3.
A video series uploaded to YouTube whenever the creators feel like it. Episodes include music news, features on the South Texas music scene, and random segments brought to the masses by the creators.
Did you see M (squared) where Melodie just jumped and and said "I'm a pretty little fairy!"... What the hell, man?
av MsquaredJALM 12. november 2007