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1.
a more colorful way of calling someone a 'hot mess', itself a way of calling someone a mess. The added color of 'tranny' and 'hot' takes the edge off of calling someone directly a 'mess'. It can have a range of connotation, from negative to neutral. Sometimes, ironically, it can be a compliment.
Alone, tranny is used as a greeting among gay men.
Gay#1: Heeey tranny.
Gay#2: HAAAY tranny!
Gay#1: Tranny, you are a hot tranny mess today; what'd you do last night?
av Tunis4Eva 12. mars 2008
 
2.
noun. "Hot tranny mess" was coined in 2008 by Christian Siriano, an American fashion designer and the winner of the fourth season of American reality show Project Runway. His remark incensed the transgendered community. He soon apologized for the remark.

The term is now used to describe generically anyone (regardless of sexual identity) who is any of these: a fashion nightmare, a bad dancer, sloppy drunk, has atrocious manners, tells hilarious off-color jokes, is very funny, is flamboyant, or whose life is in shambles or an endless comedy of errors.
Who is that hot tranny mess getting thrown out of the bar?

Oh, my God! That's too funny! You crack my ass up, you hot tranny mess!
av NickAtlanta 28. juli 2009
 
3.
used to describe a 3/4 transgender, 3/4 jewish, 4/4 terrible lefty band.
The Shondes are a hot tranny mess.
av Kay.aaRgh.Zee 5. juli 2009