Top Definition
1. People obsessed with plastic surgery.

2. What the fanbase of 'Repo! The Genetic Opera' call themselves
Person 1: I think I need another facelift

Person 2: You're such a scalpel slut

or

Scalpel Sluts are to Repo! what Juggalos are to ICP
av fellowscalpelslut 27. juni 2009

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A scalpel slut is a woman that is constantly getting surgery done in order to improve herself.
Damn, Amber is one hell of a scalpel slut.
av xxRepoManxx 3. oktober 2008

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